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任贺

  副主任医师

  副教授

  硕士生导师

  天津医科大学新世纪优秀人才

  天津市“131”人才第二层次人选

出诊时间
 
 
 

  天津市中西医结合学会胰腺疾病专业委员会

  中国抗癌协会肿瘤精准治疗专业委员会委员

  中国抗癌协会胰腺癌专业委员会青年委员

  天津市医师协会临床精准医疗专业常务委员会委员

 
 
 

  以胰腺癌为主的消化道肿瘤的综合治疗,特别是对于胰腺癌的个体化治疗,采取手术及个体化化疗及生物治疗的综合疗法,改善中晚期胰腺癌患者的预后颇有心得,同时作为主要负责人参与开展多项临床试验方案,致力于改善胰腺癌患者的生存质量及预后,此外亦擅长胃癌、结直肠癌、肝胆肿瘤的综合治疗,特别是在干细胞及DC,NK细胞生物疗法治肿瘤方面拥有丰富经验。

 
 

  主持及主要参与课题:

  1.国家自然科学基金:AKT活化的肿瘤细胞中HIF-1清除ROS的分子机制研究;2010.1-2012.12(NO.30900596);主持人

  2.国家自然科学基金:乏氧微环境下FOXP3在胰腺癌细胞中的表达调控机制及其功能研究;2013.1-2016.12(NO.81272685)主持人

  3.国家自然科学基金: HIF基因3’UTR区SNP参与胰腺癌HIF-1a表达调控的分子机制及功能研究;2014.1-2016.12(NO.81302082)第一参加人

  4.国家自然科学基金:肝癌细胞乏氧微环境下kit配基的表达调控机制及功能研究: 2010.1-2012.12(NO.30901448)第一参加人

  5.中国博士后科学基金:“HIF-1与CX3CR1/CX3CL1信号作用介导的胰腺癌嗜神经浸润研究”,2009.01-2010.12(No.20090450773)主持人

  主要发表论文:

  1.Feng Li(#), Xiao Zhao(#), Hai Wang, Ruifang Zhao, TianjiaoJi, He Ren, Gregory J. Anderson, GuangjunNie* and JihuiHao*. Multiple Layer-by-Layer Lipid-Polymer Hybrid Nanoparticles for Improved FOLFIRINOX Chemotherapy in Pancreatic Tumor Models. Advanced Functional Materials.2015;25(5):788-798. (IF: 11.805)

  2.Zhao T(#), Ren H(#), Li J(#), Chen J, Zhang H, Xin W, Sun Y, Sun L, Yang Y, Sun J, Wang X, Gao S, Huang C, Zhang H, Yang S, Hao J*. LASP1 is a HIF-1α target gene critical for metastasis of pancreatic cancer.Cancer Res.2015;75(1):111-119. (IF: 9.329)

  3.Zhao X (#), Li F (#), Li YY (#), Wang H, Ren H, Chen J, Nie GJ*,Hao JH*. Co-delivery of HIF1 siRNA and Gemcitabine via Biocompatible Lipid-polymer Hybrid Nanoparticles for Effective Treatment of Pancreatic Cancer. Biomaterials. 2015;46:13-25. (IF: 8.557)

  4.Tiansuo Zhao (#), He Ren (#), Li Jia, Jing Chen, Wen Xin, Fan Yan, Jing Li, Xiuchao Wang, Song Gao, Dong Qian, Chongbiao Huang,JihuiHao*. Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma. Oncotarget. 2015;6(4):2250-2262.(IF: 6.359)

  5.Xiao Zhao (#), Song Gao (#), He Ren, Wei Sun, Huan Zhang, Jianwei Sun, Shengyu Yang, JihuiHao*. HIF-1 promotes pancreatic ductal adenocarcinoma invasion and metastasis by activating transcription of the actin-bundling protein fascin. Cancer Res. 2014;74(9):2455-2464. (IF: 9.329)

  6.Wang X (#), Ren H (#), Zhao T, Chen J, Sun W, Sun Y, Ma W, Wang J, Gao C, Gao S, Lang M, Jia L*, Hao J*. Stem cell factor is a novel independent prognostic biomarker for hepatocellular carcinoma after curative resection.Carcinogenesis. 2014 Oct;35(10):2283-2290. (IF: 5.334)

  7.Ren H (#), Jia L (#), Zhao T, Zhang H, Chen J, Yang S, Liu J, Yu M, Hao J*.Hypoxia inducible factor (HIF)-1α directly activates leptin receptor (Ob-R) in pancreatic cancer cells.Cancer Lett. 2014;354(1):172-180. (IF: 5.621)

  8.Zhao X(#), Gao S, Ren H, Huang H, Ji W, Hao J*.Inhibition of Autophagy Strengthens Celastrol-Induced Apoptosis in Human Pancreatic Cancer in Vitro and in Vivo Models. CurrMol Med. 2014;14(4):555-563. (IF: 3.621)

  9.Zhang H(#), Chen J(#), Liu F(#), Gao C, Wang X, Zhao T, Liu J, Gao S, Zhao X, Ren H*,HaoJ*.CypA, a Gene Downstream of HIF-1α, Promotes the Development of PDAC. PLoS One. 2014;9(3):e92824. (IF: 3.234)

  10.Chunhua Ren(#), Chao Xu(#), Dongxia Li, He Ren, Jihui Hao*, Zhimou Yang*. Gemcitabine induced supramolecular hydrogelations of aldehyde-containing short peptides. RSC Adv. 2014;4:34729-34732. (IF: 3.84)

  11.Peng Jin(#), XiaoyanJi, He Ren, Yong Tang,JihuiHao*. Resection or cryosurgery relates with pancreatic tumor type: primary pancreatic cancer with previous non-pancreatic cancer or secondary metastatic cancer within the pancreas. Pancreatology. 2014;14(1):64-70. (IF:2.837)

  12.Jin P(#), Ren H, Sun W, Xin W, Zhang H, Hao J*. Circulating IL-35 in pancreatic ductal adenocarcinoma patients. Hum Immunol. 2014;75(1):29-33.(IF: 2.138)

  13.Ren H(#), Zhang H(#), Wang X, Liu J, Yuan Z, Hao J*. Prostate-specific membrane antigen as a marker of pancreatic cancer cells. Med Oncol. 2014;31(3):857. (IF: 2.634)

  14.JunweiSun(#), Pingping Zhang, He Ren,JihuiHao*. Pancreaticoduo-denectomy and pancreaticoduo-denectomy combined with superior mesenteric-portal vein resection for elderly cancer patients. Hepatobiliary & Pancreatic Diseases International. 2014;13(4):428-434.(IF: 1.517)

  15.Sun W(#), Ren H, Gao CT, Ma WD, Luo L, Liu Y, Jin P, Hao JH*. Clinical and Prognostic Significance of Coagulation Assays in Pancreatic Cancer Patients With Absence of Venous Thromboembolism. Am J ClinOncol. 2014 Jan 7. (IF: 3.062)

  16.Ren H(#), Zhao T(#), Sun J(#), Wang X, Liu J, Gao S, Yu M, Hao J*. The CX3CL1/CX3CR1 reprograms glucose metabolism through HIF-1 pathway in pancreatic adenocarcinoma. J Cell Biochem. 2013;114(11):2603-2611. (IF: 3.368)

  17.Zhao T(#), Gao S(#), Wang X, Liu J, Duan Y, Yuan Z, Sheng J, Li S, Wang F, Yu M, Ren H*,Hao J*.Hypoxia-inducible factor-1α regulates chemotactic migration of pancreatic ductal adenocarcinoma cells through directly transactivating the CX3CR1 gene. PLoS One. 2012;7(8):e43399. (IF: 3.73)

  18.Liu F(#), Tang Y(#), Sun J, Yuan Z, Li S, Sheng J, Ren H, Hao J*. Regional intra-arterial vs. systemic chemotherapy for advanced pancreatic cancer: a systematic review and meta-analysis of randomized controlled trials. PLoS One. 2012;7(7):e40847.(IF: 3.73)

  19.Wang X(#), Liu Y(#), Ren H, Yuan Z, Li S, Sheng J, Zhao T, Chen Y, Liu F, Wang F, Huang H*, Hao J*. Polymorphisms in the hypoxia-inducible factor-1a gene confer susceptibility to pancreatic cancer. Cancer BiolTher. 2011;12(5):383-387. (IF:2.636)

  20.Liu M (#), Wang X (#), Yang Y, Li D, Ren H, Zhu Q, Chen Q, Han S, Hao J*,Zhou J*. Ectopic expression of the microtubule-dependent motor protein Eg5 promotes pancreatic tumourigenesis. J Pathol. 2010 Jun;221(2):221-228. (IF:7.429)

  21.Ren H(#)*, Zhao T(#), Wang X, Gao C, Wang J, Yu M, Hao J*.Leptin upregulates telomerase activity and transcription of human telomerase reverse transcriptase in MCF-7 breast cancer cells. BiochemBiophys Res Commun. 2010;394(1):59-63. (IF:2.297)

  22.Wang D, Chen K, Du WT, Han ZB, Ren H, Chi Y, Yang SG, Bayard F, Zhu D, Han ZC. CD14+ monocytes promote the immunosuppressive effect of human umbilical cord matrix stem cells. Exp Cell Res. 2010,316(15):2414-2423. (IF=3.557)

  23.Chen K, Wang D, Du WT, Han ZB, Ren H, Chi Y, Yang SG, Zhu D, Bayard F, Han ZC. Human umbilical cord mesenchymal stem cells hUC-MSCs exert immunosuppressive activities through a PGE2-dependent mechanism. ClinImmunol. 2010,135(3):448-458. (IF=3.771)

 
 
 
 
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