西甲直播

　　张宁，博士，教授，PI，博士生导师。国家杰出青年科学基金获得者，973首席科学家。2001年毕业于约翰.霍普金斯大学医学院，获生化、细胞及分子生物学博士学位。现任天津医科大学副校长，天津市基础医学研究中心主任，天津医科大学附属肿瘤医院研究所中心实验室PI，中国抗癌协会副秘书长，天津市细胞学会副理事长，天津市生物医学工程学会副理事长。

　　长期从事生物医学及细胞生物学研究，围绕癌转移这一关键临床难题，从机理研究、生物标志物鉴定、药物筛选、纳米技术等多个侧面入手展开转化应用研究，取得了一系列科研成果。初步揭示了一个调控癌细胞趋化运动的信号传导通路。建立了一个新的药物筛选细胞模型，筛选获得两个先导化合物，一个抗癌转移化合物，已申请专利并开展临床前研究工作。近年来开始将研究领域拓展至纳米肿瘤学领域，致力于纳米技术在肿瘤诊疗中的应用研究。近五年在Cancer Research、ACS Nano、Journal of Clinical Investigation等国际期刊中发表SCI文章35篇，总IF为159.816，其中24篇为通讯作者或共同通讯作者；申请国家级专利7项，其中1项已授权；作为项目负责人，承担了国家973重大科学研究计划纳米领域项目1项、国家杰出青年科学基金1相、863课题1项、国家自然基金3项、科技部攻关子项目1项、省部级课题4项。张宁教授的工作得到国内外同行的认可，因此先后成为国家杰出青年基金获得者，获得天津市青年科技奖，被评为天津市十佳杰出留学人员，获得教育部新世纪优秀人才称号等。

　　代表性论文

    1、De Yang, Yuliang Zhao, Hua Guo, Yana Li, Poonam Tewary, Gengmei Xing, Wei Hou, Joost J. Oppenheim, and Ning Zhang*. [Gd@C(82)(OH)(22)](n) Nanoparticles Induce Dendritic Cell Maturation and Activate Th1 Immune Responses. ACS Nano. 2010 Feb 23;4(2):1178-86.(通讯作者) IF=11.421

    2、Fei Zhang, Xiaofang Zhang, Menghui Li, Peng Chen, Bin Zhang, Hua Guo, Wenfeng Cao, Xiying Wei, Xuchen Cao, Xishan Hao, Ning Zhang*. mTOR Complex Component Rictor Interacts with PKC{zeta} and Regulates Cancer Cell Metastasis. Cancer Research. 2010 Nov 15; 70(22):9360-70. (通讯作者)IF=7.856

    3、Ying Qu, Jinhua Wang, Partha S. Ray, Hua Guo, Jian Huang, Miyung Shin-Sim, Bolanle A. Bukoye, Bingya Liu, Adrian V. Lee, Xin Lin, Peng Huang, John W. Martens, Armando E. Giuliano, Ning Zhang*, Ning-Hui Cheng*, Xiaojiang Cui*. Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling. Journal of Clinical Investigation. 2011 Jan 4;121(1):212-25 (共同通讯作者) IF=13.069

    4、Jiajia Hu, Hua Guo, Hongyan Li, Yan Liu, Jingjing Liu, Liwei Chen, Jin Zhang, Ning Zhang. MiR-145 Regulates Epithelial to Mesenchymal Transition of Breast Cancer Cells by Targeting Oct4. PLoS One. 2012;7(9):e4596 (通讯作者) IF=4.092

    5、Fei Zhang, Lin Zhang, Bin Zhang, Xiyin Wei, Yi Yang, Robert Zhong Qi, Guoguang Ying, Ning Zhang* , Ruifang Niu*. Anxa2 plays a critical role in enhanced invasiveness of the multidrug resistant human breast cancer cells. Journal of Proteome Research. 2009 Nov;8(11):5041-7.(共同通讯作者)IF=5.113

    6、Baogang Zhang, Yongjie Ma,Hua Guo, Baocun Sun, Ruifang Niu, Guoguang Ying, and Ning Zhang*. Akt2 Is Required for Macrophage Chemotaxis. European Journal of Immunology 2009 Mar;39(3):894-901 (通讯作者) IF=5.103

    7、Hua Guo, Yongjie Ma, Baogang Zhang, Baocun Sun, Ruifang Niu, Guoguang Ying, and Ning Zhang*. Pivotal Advance: PKC zeta is required for migration of macrophages. Journal of Leukocyte Biology 2009 Jun;85(6):911-8.(通讯作者) IF=4.992

    8、Ying Liu, Jingna Wang, Min Wu, Wuzhou Wan, Ronghua Sun, De Yang, Xiangjun Sun, Dalong Ma, Guoguang Ying*, Ning Zhang*. Down-regulation of 3-phosphoinositide -dependent protein kinase-1 levels inhibits migration and experimental metastasis of human breast cancer cells. Molecular Cancer Research 2009 Jun;7(6):944-54.(共同通讯作者) IF=4.288

    9、Jingna Wang, Wuzhou Wan, Ronghua Sun, Ying Liu, Xiangjun Sun, Dalong Ma, Ning Zhang*. Reduction of Akt2 expression inhibits chemotaxis signal transduction in human breast cancer cells. Cellular Signalling 2008 Jun;20(6):1025-34.(通讯作者) IF=4.058

    10、Ronghua Sun, Ping Gao, Lin Chen, Dalong Ma, Jiming Wang, Joost J. Oppenheim, Ning Zhang*. Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells. Cancer Research. 2005 Feb 15; 65(4):1433-41. (通讯作者) IF=7.856

承担的科研项目

                                                                                （肿瘤细胞生物学实验室）